FG-nucleoporins caught in the act of liquid–liquid phase separation
نویسندگان
چکیده
منابع مشابه
Caught in the act
Along with replication and mutability, living beings are set apart from the mineral background they inhabit by their metabolism—their ability to catalyse chemical reactions. Since Linus Pauling first proposed that these reactions are made pos sible by enzymes that recognize and bind tightly to their substrates at a crucial transi tion point [1], it has become increasingly clear that understan...
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Galaxies are thought to be surrounded by massive halos of dark matter, each outweighing its galaxy by a factor of about eight. The visible part of a galaxy, occupying the inner 10% of the halo, consists of a mixture of stars and gas. Galaxies harbour a giant black hole at their centres, which in some cases is actively fuelled as it sucks in surrounding gas. In especially active galaxies, called...
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The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.
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Intrinsically disordered and phenylalanine-glycine-rich nucleoporins (FG Nups) form a crowded and selective transport conduit inside the NPC that can only be transited with the help of nuclear transport receptors (NTRs). It has been shown in vitro that FG Nups can assemble into two distinct appearances, amyloids and hydrogels. If and how these phenomena are linked and if they have a physiologic...
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Mitochondria in the protist Brevimastigomonas motovehiculus are in the process of dismantling their mitochondrial electron transport chain complexes as they adapt to anaerobic environments. Novel protein interactions suggest a highly complicated process rather than the simple removal of unnecessary genes.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2019
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201910211